When I first came to GISS, Jim Hansen (who is from Iowa) posed a question that filtered down to me, then the only agronomist in the building on 112th St. in Manhattan (New York not Kansas). The question was: Given the projections from the GISS global climate model for how climate would change with increased carbon dioxide, what would happen to food? Jim's question set me on the research path that I am still following, lo these years later. Look-outs along the way include temperature and water interactions, role of carbon dioxide, climate extremes, multi-model intercomparisons, and now nutrition, diet, and food security. NASA missions and models have been valuable at every step of the way. I will touch briefly on climate change and cities (where the food consumers mostly live), since GISS, after all, is located in New York City.